Cremation practices and the creation of monument complexes: the Neolithic cremation cemetery at Forteviot, Strathearn, Perth & Kinross, Scotland, and its comparanda

Around the beginning of the 3rd millennium cal bc a cremation cemetery was established at Forteviot, central Scotland. This place went on to become one of the largest monument complexes identified in Mainland Scotland, with the construction of a palisaded enclosure, timber structures, and a series of henge monuments and other enclosures. The cemetery was established between 3080 and 2900 cal bc, probably in the 30th century cal bc, which is contemporary with the cremation cemetery at Stonehenge. Nine discrete deposits of cremated bone, representing the remains of at least 18 people, were identified. In most instances they were placed within cut features and, in one case, a series of cremation deposits was associated with a broken standing stone. This paper includes the first detailed assessment of the cremated remains at Forteviot and the features associated with the cemetery, and explores how the establishment of this cemetery may have been both a catalyst and inspiration for the elaborate monument building and prolonged acts of remembrance that occurred at this location over a period of almost 1000 years. The paper also outlines the parallels for Forteviot across Britain and, for the first time, draws together the dating evidence (including Bayesian modelling) for this major category of evidence for considering the nature of late 4th/early 3rd millennium cal bc society. The results and discussion have wide implications and resonances for contemplating the establishment and evolution of monument complexes in prehistoric Britain and beyond

Restoration of SMN in Schwann cells reverses myelination defects and improves neuromuscular function in spinal muscular atrophy

Spinal muscular atrophy (SMA) is a neuromuscular disease caused by low levels of SMN protein, primarily affecting lower motor neurons. Recent evidence from SMA and related conditions suggests that glial cells can influence disease severity. Here, we investigated the role of glial cells in the peripheral nervous system by creating SMA mice selectively overexpressing SMN in myelinating Schwann cells (Smn(−/−);SMN2(tg/0);SMN1(SC)). Restoration of SMN protein levels restricted solely to Schwann cells reversed myelination defects, significantly improved neuromuscular function and ameliorated neuromuscular junction pathology in SMA mice. However, restoration of SMN in Schwann cells had no impact on motor neuron soma loss from the spinal cord or ongoing systemic and peripheral pathology. This study provides evidence for a defined, intrinsic contribution of glial cells to SMA disease pathogenesis and suggests that therapies designed to include Schwann cells in their target tissues are likely to be required in order to rescue myelination defects and associated disease symptoms

AN Ultrasonic Ray-Trance Code for Complex Geometry Applications

Many applications of ultrasonic testing (UT) are made difficult by the complex geometrical shape of the part to be inspected. A simple ray-trace analysis of the geometry may suffice to determine transducer positions and beam angles to provide adequate coverage of the region to be interrogated. In addition, however, the analyst must have estimates of backscattered amplitudes to determine if flaw signals are measurable. Thus, a combination of complex-geometry ray tracing with calculations of flaw-scattering amplitudes is required for the design and optimization of UT procedures